For the loser, well, the indignity of losing to your Manchester rivals is simply bad enough on its own.
City will be disappointed to have lost in the FA Cup on Sunday, but they have four days to get over that and presumably their supporters will forgive them if they can land a handsome victory over United here.
The Red Devils could be without Paul Pogba, who is battling an injury, while Marco Rojo and Zlatan Ibrahimovic are definitely out. Chris Smalling and Juan Mata face late fitness tests too, and quite frankly we cannot see a patched-up United side keeping City at bay even if Jose Mourinho is the master at these backs-to-the-wall missions.
But then City could be without Fernandinho, Sergio Aguero and David Silva, who all picked dup muscle injuries recently, so perhaps waiting until the teams are announced is the smart move here.
With all that being said, City at 19/20 look outstanding value on home soil.
Manchester City to Win (19/20 with bet365)